Categories

papers

Chaperone regulation of biomolecular condensates
Transcriptome-wide mRNA condensation precedes stress granule formation and excludes stress-induced transcripts
An adaptive biomolecular condensation response is conserved across environmentally divergent species
HDX-MS finds that partial unfolding with sequential domain activation controls condensation of a cellular stress marker
Single-molecule fluorescence multiplexing by multi-parameter spectroscopic detection of nanostructured FRET labels
Adaptive preservation of orphan ribosomal proteins in chaperone-stirred condensates
Pervasive, conserved secondary structure in highly charged protein regions
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules
Using fluorescence anisotropy to monitor chaperone dispersal of RNA-binding protein condensates
Chaperones directly and efficiently disperse stress-triggered biomolecular condensates
Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly
Daily cycles of reversible protein condensation in cyanobacteria
Transient intracellular acidification regulates the core transcriptional heat shock response
Live cell measurement of the intracellular pH of yeast by flow cytometry using a genetically-encoded fluorescent reporter
Cellular sensing by phase separation: Using the process, not just the products
A Nobel Prize for evolution
An Escherichia coli nitrogen starvation response is important for mutualistic coexistence with Rhodopseudomonas palustris
Stress-triggered phase separation is an adaptive, evolutionarily tuned response
Heat Shock Factor 1: from fire chief to crowd-control specialist
Reversible, specific, active aggregates of endogenous proteins assemble upon heat stress
Dying mRNA tells a story of its life
Accounting for experimental noise reveals that mRNA levels, amplified by post-transcriptional processes, largely determine steady-state protein levels in yeast
A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus
Estimating a structured covariance matrix from multi-lab measurements in high-throughput biology
Quantifying condition-dependent intracellular protein levels enables high-precision fitness estimates
Estimating selection on synonymous codon usage from noisy experimental data
How infidelity creates a sticky situation
Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme
Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast
Signatures of protein biophysics in coding sequence evolution
The evolutionary consequences of erroneous protein synthesis
Protein evolution: innovative chaps
Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution
Contact density affects protein evolutionary rate from bacteria to animals
A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments
Structural determinants of the rate of protein evolution in yeast
Population genetics of translational robustness
A single determinant dominates the rate of yeast protein evolution
Why highly expressed proteins evolve slowly
Predicting the tolerance of proteins to random amino acid substitution
Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins
On the conservative nature of intragenic recombination
Thermodynamic prediction of protein neutrality

paper

team

news

projects

project

protocols

protocol

blog

data