D. Allan Drummond

Principal investigator
Google Scholar

Allan is Associate Professor of Biochemistry & Molecular Biology at the University of Chicago, with a secondary appointment in the Department of Medicine, Section of Genetic Medicine. He joined the UChicago faculty in 2011.

Allan started the group at Harvard University as a Bauer Fellow at the FAS Center for Systems Biology, where he spent five years. He received his Ph.D. in Computation and Neural Systems from Caltech advised by Frances H. Arnold.

Prior to entering science, Allan worked at Trilogy for seven years in multiple roles, the last as an HR director responsible for training and leadership development as director of Trilogy University.


Chaperone regulation of biomolecular condensates

Transcriptome-wide mRNA condensation precedes stress granule formation and excludes stress-induced transcripts

An adaptive biomolecular condensation response is conserved across environmentally divergent species

HDX-MS finds that partial unfolding with sequential domain activation controls condensation of a cellular stress marker

Single-molecule fluorescence multiplexing by multi-parameter spectroscopic detection of nanostructured FRET labels

Adaptive preservation of orphan ribosomal proteins in chaperone-stirred condensates

Pervasive, conserved secondary structure in highly charged protein regions

Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules

Using fluorescence anisotropy to monitor chaperone dispersal of RNA-binding protein condensates

Chaperones directly and efficiently disperse stress-triggered biomolecular condensates

Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly

Daily cycles of reversible protein condensation in cyanobacteria

Transient intracellular acidification regulates the core transcriptional heat shock response

Live cell measurement of the intracellular pH of yeast by flow cytometry using a genetically-encoded fluorescent reporter

Cellular sensing by phase separation: Using the process, not just the products

A Nobel Prize for evolution

An Escherichia coli nitrogen starvation response is important for mutualistic coexistence with Rhodopseudomonas palustris

Stress-triggered phase separation is an adaptive, evolutionarily tuned response

Heat Shock Factor 1: from fire chief to crowd-control specialist

Reversible, specific, active aggregates of endogenous proteins assemble upon heat stress

Dying mRNA tells a story of its life

Accounting for experimental noise reveals that mRNA levels, amplified by post-transcriptional processes, largely determine steady-state protein levels in yeast

A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus

Estimating a structured covariance matrix from multi-lab measurements in high-throughput biology

Quantifying condition-dependent intracellular protein levels enables high-precision fitness estimates

Estimating selection on synonymous codon usage from noisy experimental data

How infidelity creates a sticky situation

Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme

Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast

Signatures of protein biophysics in coding sequence evolution

The evolutionary consequences of erroneous protein synthesis

Protein evolution: innovative chaps

Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution

Contact density affects protein evolutionary rate from bacteria to animals

A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments

Structural determinants of the rate of protein evolution in yeast

Population genetics of translational robustness

A single determinant dominates the rate of yeast protein evolution

Why highly expressed proteins evolve slowly

Predicting the tolerance of proteins to random amino acid substitution

Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins

On the conservative nature of intragenic recombination

Thermodynamic prediction of protein neutrality


Sticking together to survive stress

Parting poetry from a peerless postdoc

Rethinking heat-induced aggregation

Testing MathJax

A new site