D. Allan Drummond

Principal investigator
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dadrummondobfuscate@uchicago.edu

Allan is an Assistant Professor at the University of Chicago in the Department of Biochemistry & Molecular Biology, with a secondary appointment in the Department of Human Genetics.

Allan started the group at Harvard University as a Bauer Fellow at the FAS Center for Systems Biology, where he spent five years. He received his Ph.D. in Computation and Neural Systems from Caltech.

Prior to entering science, Allan worked at Trilogy for seven years in multiple roles, the last as an HR director responsible for training and leadership development as director of Trilogy University.

Papers

Stress-triggered phase separation is an adaptive, evolutionarily tuned response

Heat Shock Factor 1: from fire chief to crowd-control specialist

Reversible, specific, active aggregates of endogenous proteins assemble upon heat stress

Dying mRNA tells a story of its life

Accounting for experimental noise reveals that mRNA levels, amplified by post-transcriptional processes, largely determine steady-state protein levels in yeast

A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus

Estimating a structured covariance matrix from multi-lab measurements in high-throughput biology

Quantifying condition-dependent intracellular protein levels enables high-precision fitness estimates

Estimating selection on synonymous codon usage from noisy experimental data

How infidelity creates a sticky situation

Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme

Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast

Signatures of protein biophysics in coding sequence evolution

The evolutionary consequences of erroneous protein synthesis

Protein evolution: innovative chaps

Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution

Contact density affects protein evolutionary rate from bacteria to animals

A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments

Structural determinants of the rate of protein evolution in yeast

Population genetics of translational robustness

A single determinant dominates the rate of yeast protein evolution

Why highly expressed proteins evolve slowly

Predicting the tolerance of proteins to random amino acid substitution

Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins

On the conservative nature of intragenic recombination

Thermodynamic prediction of protein neutrality

Posts

Sticking together to survive stress

Parting poetry from a peerless postdoc

Rethinking heat-induced aggregation

Testing MathJax

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