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papers
Chaperone regulation of biomolecular condensates
Transcriptome-wide mRNA condensation precedes stress granule formation and excludes stress-induced transcripts
An adaptive biomolecular condensation response is conserved across environmentally divergent species
HDX-MS finds that partial unfolding with sequential domain activation controls condensation of a cellular stress marker
Single-molecule fluorescence multiplexing by multi-parameter spectroscopic detection of nanostructured FRET labels
Adaptive preservation of orphan ribosomal proteins in chaperone-stirred condensates
Pervasive, conserved secondary structure in highly charged protein regions
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules
Using fluorescence anisotropy to monitor chaperone dispersal of RNA-binding protein condensates
Chaperones directly and efficiently disperse stress-triggered biomolecular condensates
Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly
Daily cycles of reversible protein condensation in cyanobacteria
Transient intracellular acidification regulates the core transcriptional heat shock response
Live cell measurement of the intracellular pH of yeast by flow cytometry using a genetically-encoded fluorescent reporter
Cellular sensing by phase separation: Using the process, not just the products
A Nobel Prize for evolution
An Escherichia coli nitrogen starvation response is important for mutualistic coexistence with Rhodopseudomonas palustris
Stress-triggered phase separation is an adaptive, evolutionarily tuned response
Heat Shock Factor 1: from fire chief to crowd-control specialist
Reversible, specific, active aggregates of endogenous proteins assemble upon heat stress
Dying mRNA tells a story of its life
Accounting for experimental noise reveals that mRNA levels, amplified by post-transcriptional processes, largely determine steady-state protein levels in yeast
A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus
Estimating a structured covariance matrix from multi-lab measurements in high-throughput biology
Quantifying condition-dependent intracellular protein levels enables high-precision fitness estimates
Estimating selection on synonymous codon usage from noisy experimental data
How infidelity creates a sticky situation
Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme
Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast
Signatures of protein biophysics in coding sequence evolution
The evolutionary consequences of erroneous protein synthesis
Protein evolution: innovative chaps
Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution
Contact density affects protein evolutionary rate from bacteria to animals
A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments
Structural determinants of the rate of protein evolution in yeast
Population genetics of translational robustness
A single determinant dominates the rate of yeast protein evolution
Why highly expressed proteins evolve slowly
Predicting the tolerance of proteins to random amino acid substitution
Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins
On the conservative nature of intragenic recombination
Thermodynamic prediction of protein neutrality
paper
Chaperone regulation of biomolecular condensates
Transcriptome-wide mRNA condensation precedes stress granule formation and excludes stress-induced transcripts
An adaptive biomolecular condensation response is conserved across environmentally divergent species
HDX-MS finds that partial unfolding with sequential domain activation controls condensation of a cellular stress marker
Single-molecule fluorescence multiplexing by multi-parameter spectroscopic detection of nanostructured FRET labels
Adaptive preservation of orphan ribosomal proteins in chaperone-stirred condensates
Pervasive, conserved secondary structure in highly charged protein regions
Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules
Using fluorescence anisotropy to monitor chaperone dispersal of RNA-binding protein condensates
Chaperones directly and efficiently disperse stress-triggered biomolecular condensates
Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly
Daily cycles of reversible protein condensation in cyanobacteria
Transient intracellular acidification regulates the core transcriptional heat shock response
Live cell measurement of the intracellular pH of yeast by flow cytometry using a genetically-encoded fluorescent reporter
Cellular sensing by phase separation: Using the process, not just the products
A Nobel Prize for evolution
An Escherichia coli nitrogen starvation response is important for mutualistic coexistence with Rhodopseudomonas palustris
Stress-triggered phase separation is an adaptive, evolutionarily tuned response
Heat Shock Factor 1: from fire chief to crowd-control specialist
Reversible, specific, active aggregates of endogenous proteins assemble upon heat stress
Dying mRNA tells a story of its life
Accounting for experimental noise reveals that mRNA levels, amplified by post-transcriptional processes, largely determine steady-state protein levels in yeast
A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus
Estimating a structured covariance matrix from multi-lab measurements in high-throughput biology
Quantifying condition-dependent intracellular protein levels enables high-precision fitness estimates
Estimating selection on synonymous codon usage from noisy experimental data
How infidelity creates a sticky situation
Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme
Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast
Signatures of protein biophysics in coding sequence evolution
The evolutionary consequences of erroneous protein synthesis
Protein evolution: innovative chaps
Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution
Contact density affects protein evolutionary rate from bacteria to animals
A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments
Structural determinants of the rate of protein evolution in yeast
Population genetics of translational robustness
A single determinant dominates the rate of yeast protein evolution
Why highly expressed proteins evolve slowly
Predicting the tolerance of proteins to random amino acid substitution
Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins
On the conservative nature of intragenic recombination
Thermodynamic prediction of protein neutrality
team
Alyssa Guzman
Jeffery Zhang
Karen Velez
Estefania Cuevas-Zepeda
Leah Chaney Winner
Dana Christopher
Josh Melamed
Kyle Lin
Titilayo Arowolo
Rosalind Pan
Caitlin Wong Hickernell
Hendrik Glauninger
Jared Bard
Sammy Keyport Kik
Aparna Srinivasan
Haneul Yoo
Daniel Ruttenberg
Weronika Danecka
Jakub Kucharczyk
Catherine Triandafillou
Rohan Goyal
Chris Katanski
Eliza Nieweglowska
Joshua Riback
Pawel Laskowski
Evgeny Pilipenko
Alexandra Rojek
Joseph Park
Jamie L. Scott
Kerry Geiler-Samerotte
Edward W. J. Wallace
D. Allan Drummond
news
Flipping the script on heat shock
Caitlin defends her thesis
Chaperone regulation of biomolecular condensates: new review!
Conservation of condensation paper featured!
RNA condensation preprint
Conservation of condensation paper published!
Pab1 HDX paper accepted!
Jared starts his own lab!
Conservation of condensation preprint
Hendrik defends his thesis
Sammy and Caitlin win poster prizes
Sammy defends her thesis
Kyle wins F30
Dana named IBD Scholar
Josh wins BSCD fellowship
Rosalind graduates summa cum laude
Stress granule review published
Haneul wins overall best dissertation
Condensate dispersal protocol published
Haneul wins best thesis prize
Chaperone paper published
Chaperone paper accepted
NIH MIRA funds us for next 5 years
Haneul Yoo defends her thesis
Caitlin wins F31
Hendrik wins F30
Kyle wins the Grier Prize
Rosalind wins Liew Fellowship
Sammy wins F31
Hsf1 and pH paper accepted
Cat Triandafillou defends her thesis
Jared wins Helen Hay Whitney fellowship
Haneul wins F31
New review on phase separation
Chris Katanski defends his thesis
Jared Bard joins the lab
Sammy Keyport joins the lab
Josh Riback defends his thesis
Allan is a 2018 Scialog Fellow
Allan is promoted with tenure
Allan receives BIV junior faculty award
Chris wins poster prize
Josh wins a Harper Fellowship
Allan receives Distinguished Investigator award
'How heat kills cells'
New paper on stress-triggered phase separation
Haneul's a Ph.D. candidate
Haneul passes her prelim
HSF1 perspective in Molecular Cell
Haneul Yoo joins the lab
A CBC Catalyst award to study asymmetric inheritance
3D printing yeast and stress granules
Cat passes her prelim
More coverage of our aggregation paper
Coverage of our aggregation paper
New paper on stress-induced protein aggregation
Allan wins W.J. Youden award
Perspective in Cell
Alexandra wins the L.J. Henderson thesis prize
EMBO poster prize
Alexandra wins Hoopes thesis prize
New PLOS Genetics paper
Edward awarded CBC postdoc grant
Edward wins ASBMB poster prize
New PLOS Biology paper
BIG Seed award
Chris Katanski joins the lab
Josh wins an NSF fellowship
projects
Evolution of protein synthesis
Protein misfolding and gene expression
Engineering self-assembling proteins
Stress, signaling, and biomolecular condensation
project
Evolution of protein synthesis
Protein misfolding and gene expression
Engineering self-assembling proteins
Stress, signaling, and biomolecular condensation
protocols
Using fluorescence anisotropy to monitor chaperone dispersal of RNA-binding protein condensates
Measuring translation in yeast using a PEST-nanoluciferase reporter
Measuring translation in yeast by liquid scintillation counting
RNATagSeq: multiplexed library preparation for Illumina RNA sequencing
Yeast total RNA isolation protocol
Sucrose gradient protocol for polysome profiles
Anti-RNA blotting with chemiluminescent detection
Supernatant/pellet fractionation of budding yeast cells by cryogenic lysis
Chloroform-methanol extraction of proteins
protocol
Using fluorescence anisotropy to monitor chaperone dispersal of RNA-binding protein condensates
Measuring translation in yeast using a PEST-nanoluciferase reporter
Measuring translation in yeast by liquid scintillation counting
RNATagSeq: multiplexed library preparation for Illumina RNA sequencing
Yeast total RNA isolation protocol
Sucrose gradient protocol for polysome profiles
Anti-RNA blotting with chemiluminescent detection
Supernatant/pellet fractionation of budding yeast cells by cryogenic lysis
Chloroform-methanol extraction of proteins
blog
Some like it hot: temperature signals across the tree of life
Sticking together to survive stress
Behind the scenes of Pab1 demixing
Polymer biophysics of Pab1: expectations vs. reality
Parting poetry from a peerless postdoc
Rethinking heat-induced aggregation
Testing MathJax
A new site
data
Disaggregation assay data visualization
Aggregation assay data visualization
outreach
Color inside the cell
South Side Science Festival
Biochemistry & Molecular Biology
The University of Chicago
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