Heat Shock Factor 1: from fire chief to crowd-control specialist

Triandafillou CG and Drummond DA, Molecular Cell 63 (1) :1—2 (2016).


HSF1 is the supposed master regulator of the heat shock response. A clever method for inactivating this essential transcription factor reveals that it has a much narrower job description: organizing a small team of molecular chaperones that keep the proteome moving. (Perspective on work by Solís et al.)