Chaperone regulation of biomolecular condensates

Bard & Drummond 2024

PREPRINT: Transcriptome-wide mRNA condensation precedes stress granule formation and excludes stress-induced transcripts

G/B/WH et al. 2024

An adaptive biomolecular condensation response is conserved across environmentally divergent species

Keyport Kik et al. 2024

HDX-MS finds that partial unfolding with sequential domain activation controls condensation of a cellular stress marker

Chen et al. 2024

Single-molecule fluorescence multiplexing by multi-parameter spectroscopic detection of nanostructured FRET labels

Chu et al. 2024

Adaptive preservation of orphan ribosomal proteins in chaperone-stirred condensates

Ali et al. 2023

Pervasive, conserved secondary structure in highly charged protein regions

Triandafillou, Pan et al. 2023

Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules

Glauninger et al. 2022

Using fluorescence anisotropy to monitor chaperone dispersal of RNA-binding protein condensates

Yoo and Drummond 2022

Chaperones directly and efficiently disperse stress-triggered biomolecular condensates

Yoo et al. 2022

Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly

Cereghetti et al. 2021

Daily cycles of reversible protein condensation in cyanobacteria

Pattanayak et al. Cell Reports 2020

Transient intracellular acidification regulates the core transcriptional heat shock response

Triandafillou et al. eLife 2020

Live cell measurement of the intracellular pH of yeast by flow cytometry using a genetically-encoded fluorescent reporter

Triandafillou and Drummond 2020

Cellular sensing by phase separation: Using the process, not just the products

Yoo et al. JBC 2019

A Nobel Prize for evolution

Drummond and Bloom Evolution 2019

An Escherichia coli nitrogen starvation response is important for mutualistic coexistence with Rhodopseudomonas palustris

McCully et al. AEM 2018

Stress-triggered phase separation is an adaptive, evolutionarily tuned response

Riback, Katanski et al. Cell 2017

Heat Shock Factor 1: from fire chief to crowd-control specialist

Triandafillou and Drummond Molecular Cell 2016

Reversible, specific, active aggregates of endogenous proteins assemble upon heat stress

Wallace et al. Cell 2015

Dying mRNA tells a story of its life

Wallace and Drummond Cell 2015

Accounting for experimental noise reveals that mRNA levels, amplified by post-transcriptional processes, largely determine steady-state protein levels in yeast

Csárdi, Franks et al. PLOS Genetics 2015

A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus

Zaborske et al. PLOS Biology 2014

Estimating a structured covariance matrix from multi-lab measurements in high-throughput biology

Franks, Csárdi et al. JASA 2014

Quantifying condition-dependent intracellular protein levels enables high-precision fitness estimates

Geiler-Samerotte et al. PLOS One 2013

Estimating selection on synonymous codon usage from noisy experimental data

Wallace et al. Mol Biol Evol 2013

How infidelity creates a sticky situation

Drummond Mol. Cell 2012

Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme

Agashe et al. Mol Biol Evol 2013

Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast

Geiler-Samerotte et al. PNAS 2011

Signatures of protein biophysics in coding sequence evolution

Wilke and Drummond Curr Opin Struct Biol 2010

The evolutionary consequences of erroneous protein synthesis

Drummond and Wilke Nat Rev Genet 2009

Protein evolution: innovative chaps

Drummond Curr Biol 2009

Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution

Drummond and Wilke Cell 2008

Contact density affects protein evolutionary rate from bacteria to animals

Zhou et al. J Mol Evol 2008

A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments

Li et al. Nat. Biotech. 2007

Structural determinants of the rate of protein evolution in yeast

Bloom et al. MBE 2006

Population genetics of translational robustness

Drummond and Wilke Genetics 2006

A single determinant dominates the rate of yeast protein evolution

Drummond et al. Mol Biol Evol 2006

Why highly expressed proteins evolve slowly

Drummond et al. PNAS 2005b

Predicting the tolerance of proteins to random amino acid substitution

Wilke et al. Biophys J 2005

Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins

Drummond et al. JMB 2005

On the conservative nature of intragenic recombination

Drummond et al. PNAS 2005a

Thermodynamic prediction of protein neutrality

Bloom et al. PNAS 2005